Body
  
1/24/2024 1:45 PM
Major extension to nonideal sedimentation coefficient distribution​
  
2/10/2017 9:55 AM

contains a new pipetting calculator to help in experimental design, and has improved performance with high-affinity systems (lower Kd-limits)​

  
5/22/2015 9:44 AM

​This is a first version of a new sister-program to SEDPHAT specialized in the analysis of ITC data. 

It has advanced tools for global modeling and experimental design.

  
5/22/2015 8:44 AM

​This version has the new residuals histogram function and a few squashed bugs.

  
1/9/2015 8:45 AM

​* new data generation tools for experimental planning

* visualization of data of heterogeneous interactions in the concentration plane

* sH/sD plot tool

  
1/9/2015 8:44 AM

​bug fixes

  
8/29/2014 12:39 PM

​Extended models for FDS data analysis including the modeling of photophysical processes, such as photoactivation and photobleaching, during the SV run

  
5/1/2013 2:57 PM

New fluorescence options can be found in the Loading Options and Fitting Options menus once fluorescence data are loaded, or by using a shortcut Alt-F.  A description will follow soon; in the meantime feel free to email schuckp@mail.nih.gov about the details.​ 

  
4/16/2013 12:39 PM

​* new function for mass conservation constraints in multi-signal sedimentation velocity analysis (MC-MSSV)

* support for upcoming new versions of NITPIC and GUSSI

* fix of several minor bugs

  
1/24/2013 12:22 PM

* can automatically check for file time-stamps and allows correction of elapsed second entry in data files when necessary​

  
1/5/2013 2:05 PM

​fixed ITC bugs

1) when manually adding .dat files exported from Origin, dependent on .dat format the last data point was not read

2) instability when subtracting reference ITC data

  
12/18/2012 3:46 PM

​new functions: subtract ITC reference data, copy error bars

bug fixes 

  
6/13/2012 10:26 AM

New release of helper programs for SEDFIT and SEDPHAT for plotting, making movies, etc.   These require MATLAB ​version 7.17 as available from the Mathworks website.

  
6/8/2012 11:57 AM

This is the first release of NITPIC on the MATLAB platform.  For requirements see the installation instructions.  This version will be updated soon with a PYTHON standalone ​version. 

  
10/17/2011 1:23 PM

* interface function to new GUSSI plots (coming soon);  Minor bug fixes.​

  
10/17/2011 1:19 PM

Update of statistical functions:

*automatic tracing of error contour plots in 1 and 2 dimensions

bug fixes​

  
6/20/2011 9:21 PM
update with new functions: * ITC analyses with unmixed neck/mixed neck option for data analyses from Microcal vs. TA Instruments data * global ITC temperature-dependent cp analysis, protonation analysis, linked binding analysis * option to exclude single data points * new user interface elements for control of data and xp parameters
  
6/7/2011 1:09 PM
dndc, extinction coefficient, vbar calculator from sequence should be 1,986560 B (1,940 KB) once extracted
  
7/1/2010 12:24 PM
most important changes: * extend copying data and fit functions to 3 component data sets * fix error in Monte-Carlo routine of spectroscopy data (did not work) * new interaction models for binary and ternary systems * make multi-threaded SV reaction kinetics models * in SV, enforce back-diffusion setting of experimental parameter box * effective particle model calculator and isotherms for two- and three-site binding * new model for competitive homo- and hetero-dimerzation * screen buttons for concentration entry in interacting models * enable ITC model for hetero-trimerization
  
7/1/2010 11:50 AM
most important changes: * fix bug causing log sign error * fix bug caused by reloading incompatible older ~.* files * allow optional fit of intensity autocorrelation data in DLS * re-enable analytical zone and synthetic boundary analysis modes * cumulant analysis for DLS data * calculator function for spread from diffusion vs spread from differential sedimentation * function for c(M) with general scaling law and calibration * add function to mirror image interference data * rename pseudo-absorbance data as "AS" and "AR" (absorbance sample side and absorbance reference side) * add plotting functionality * add s-value determination from BEST bemine files * fix potential crash in Rh = 0 case for DLS analysis * fix bug in integration of distributions with negative s-values * modify 2d distribution integration * fix bug causing intermittent crash in Bayesian analysis of 2d distribution * enable Monte Carlo for 2d distributions * incorporate HYDROPRO access as a calculator function
  
6/24/2010 1:42 PM
fixed some bugs, couple of improvements to be released with description soon.
  
8/31/2009 4:00 PM
fixed a potential crash when Rh = 0 in DLS fit
  
7/31/2009 11:59 AM
this is the same as 1180, with a bug fixed where negative s-values as integration limits could cause a crash
  
6/29/2009 3:56 PM
changes since last release: 10/10/08: * fix recent bug when using hybrid discrete/continuous model for sedimentation equilibrium 09/27/08: * eliminate potential problem when using self-association with mass conservation and linking concentrations from xp with unequal # of scans renamed version 6.22 beta 09/18/08: * include correction factor for concentrations in isotherms 09/15/08: * improve optimizing extinction coefficient in the multi-wavelength SV hybrid discrete/continuous model 08/19/08: * allow saving partial boundary raw data
  
6/29/2009 3:54 PM
most important changes from previous release (11.72c): 05/58/09: * fix bug that caused instances where fitted line in plots of isotherm fits was drawn wrong 05/20/09: * modify 2d distribution integration 05/20/09: * fix bug causing intermittent crash in Bayesian analysis of 2d distribution 04/27/09: * enable Monte Carlo for 2d distributions 04/28/09: * incorporate HYDROPRO access as a calculator function renamed version 11.74 03/12/09: * rotor speed estimator for SE in calculator functions 03/11/09: * minimum time to equilibrium estimator in the calculator functions 03/04/09: * general scaling law model for c(s) 03/04/09: * supress warning about meniscus and bottom fitting limits when not fitting meniscus and bottom 03/04/09: * make wwt option switch back after done with ls-g*(s) 03/04/09: * don't flag fluorescence data for too steep gradients 03/04/09: * make user-defined time interval for updating the best-fit plots during fits 03/04/09: * make model for bimodal frictional ratio with extra species 03/05/09: * allow integrating particle size distributions from DLS renamed version 11.73a 09/15/08: * include corrections for time-offests in absorbance scans accounting for the scan time from first data point to meniscus renamed version 11.72f 08/21/08: * make Lamm equation parameter box ask about saving only when anything changes 08/21/08: * rearrange memory allocation at startup for better stability renamed version 11.72e 08/21/08: * fix overflow error for back-diffusion test of very large species for low values of right fitting limit
  
2/12/2009 2:29 PM
renamed version 11.72c 08/07/08: * fix bug for data that start the comment line with a filetype identifier character renamed version 11.72b 08/01/08: * fix instability when fitting limits are not set 08/01/08: * fix bug occasionally adding integral offset to dissected 6-channel data 07/31/08: * suppress repainting when loading files and entering parameters. renamed version 11.72 07/25/08: * fix question to set meniscus and bottom when fitting DLS data 07/25/08: * change compiler optimization settings (Pentium) 07/25/08: * make user defined defaults for Lamm equation parameters
  
2/12/2009 2:29 PM
renamed version 11.71
07/16/08: * flag gradients that exceed an upper limit
07/15/08: * flag when rotor acceleration is unusually slow (likely error arising from temperature equilibration at 3000 rpm)
07/15/08: * in calculator: fix bug reversing the ellipsoidal ratios of oblate and prolate models
07/05/08: * update xp export file to sedphat
07/03/08: * make debugging system dumping info to files  
06/20/08: * make new input box for inhomogeneous solvent model
06/20/08: * make dynamic density gradients take advantage of multi-threaded CLamm class
06/11/08: * include scanning time corrections to ls-g*(s) [is incompatible with compressibility option]
06/11/08: * include scanning time corrections to van Holde-Weischet
renamed version 11.5 (beta)
05/20/08: * fix crash when using van Holde-Weischet model.
05/20/08: * fix bug causing error message when switching models in DLS analysis
05/20/08: * eliminate possibility to transform distributions twice, and to integrate transformed distributions
renamed version 11.4
05/02/08: * dynamic limit dragging
04/29/08: * take advantage of multithreading for Lamm equation solutions in distributions.
04/23/08: * improve automatic determination of peak width
04/11/08: * fix bug in positioning of the peak Mw info boxes appearing on control-M
04/11/08: * fix bug that would overwrite new vbar value when using the vbar menu function while using continuous distribution models
04/11/08: * enable ls-g*(s) in new Lamm equation class
04/03/08: * make menu point to transform s(xp) to s(20,w)
04/01/08: * fix bug when reloading fit parameters including 'times from wwt' option
04/01/08: * fix bug when generating data with short time interval making a scan time fall into the rotor acceleration phase
04/01/08: * new structure of Lamm equation solutions
renamed version 11.3c
03/27/08: * fix bug resulting in wrong concentrations when generating data with the discrete species model
03/27/08: * increase precision in the amplitude field of the prior parameter box
03/27/08: * allow fitting of synthetic boundary experiments
03/27/08: * fix bug in Lamm equation parameter box not allowing experimental initial conditions to be switched on
renamed version 11.3b
02/19/08: * fix bug in generating synthetic data with c(s) model
renamed version 11.3
02/06/08: * make rotor acceleration the default for SV analysis
02/06/08: * change default crossover for sedimentation algorithms
02/06/08: * improved error catching for Lamm simulations
renamed version 11.2
01/23/08: * fix bug causing crash when using s-grid from file option
01/08/08: * fix bug under certain conditions causing discretization error in Lamm algorithm
01/08/08: * fix bug in switching Lamm simulation methods in distributions at high s-values
01/08/08: * introduce radial reconvolution