| | 1/24/2024 1:45 PM | Major extension to nonideal sedimentation coefficient distribution |
| | 2/10/2017 9:55 AM | contains a new pipetting calculator to help in experimental design, and has improved performance with high-affinity systems (lower Kd-limits) |
| | 5/22/2015 9:44 AM | This is a first version of a new sister-program to SEDPHAT specialized in the analysis of ITC data.
It has advanced tools for global modeling and experimental design.
|
| | 5/22/2015 8:44 AM | This version has the new residuals histogram function and a few squashed bugs.
|
| | 1/9/2015 8:45 AM | * new data generation tools for experimental planning
* visualization of data of heterogeneous interactions in the concentration plane
* sH/sD plot tool |
| | 1/9/2015 8:44 AM | |
| | 8/29/2014 12:39 PM | Extended models for FDS data analysis including the modeling of photophysical processes, such as photoactivation and photobleaching, during the SV run |
| | 5/1/2013 2:57 PM | New fluorescence options
can be found in the Loading Options and Fitting Options menus once fluorescence
data are loaded, or by using a shortcut Alt-F. A description will follow soon; in the meantime feel free to email schuckp@mail.nih.gov about the details. |
| | 4/16/2013 12:39 PM | * new function for mass conservation constraints in multi-signal sedimentation velocity analysis (MC-MSSV)
* support for upcoming new versions of NITPIC and GUSSI
* fix of several minor bugs
|
| | 1/24/2013 12:22 PM | * can automatically check for file time-stamps and allows correction of elapsed second entry in data files when necessary |
| | 1/5/2013 2:05 PM | fixed ITC bugs
1) when manually adding .dat files exported from Origin, dependent on .dat format the last data point was not read
2) instability when subtracting reference ITC data |
| | 12/18/2012 3:46 PM | new functions: subtract ITC reference data, copy error bars
bug fixes |
| | 6/13/2012 10:26 AM | New release of helper programs for SEDFIT and SEDPHAT for plotting, making movies, etc. These require MATLAB version 7.17 as available from the Mathworks website. |
| | 6/8/2012 11:57 AM | This is the first release of NITPIC on the MATLAB platform. For requirements see the installation instructions. This version will be updated soon with a PYTHON standalone version. |
| | 10/17/2011 1:23 PM | * interface function to new GUSSI plots (coming soon); Minor bug fixes. |
| | 10/17/2011 1:19 PM | Update of statistical functions:
*automatic tracing of error contour plots in 1 and 2 dimensions
bug fixes |
| | 6/20/2011 9:21 PM | update with new functions:
* ITC analyses with unmixed neck/mixed neck option for data analyses from Microcal vs. TA Instruments data
* global ITC temperature-dependent cp analysis, protonation analysis, linked binding analysis
* option to exclude single data points
* new user interface elements for control of data and xp parameters |
| | 6/7/2011 1:09 PM | dndc, extinction coefficient, vbar calculator from sequence
should be 1,986560 B (1,940 KB) once extracted |
| | 7/1/2010 12:24 PM | most important changes:
* extend copying data and fit functions to 3 component data sets
* fix error in Monte-Carlo routine of spectroscopy data (did not work)
* new interaction models for binary and ternary systems
* make multi-threaded SV reaction kinetics models
* in SV, enforce back-diffusion setting of experimental parameter box
* effective particle model calculator and isotherms for two- and three-site binding
* new model for competitive homo- and hetero-dimerzation
* screen buttons for concentration entry in interacting models
* enable ITC model for hetero-trimerization
|
| | 7/1/2010 11:50 AM | most important changes:
* fix bug causing log sign error
* fix bug caused by reloading incompatible older ~.* files
* allow optional fit of intensity autocorrelation data in DLS
* re-enable analytical zone and synthetic boundary analysis modes
* cumulant analysis for DLS data
* calculator function for spread from diffusion vs spread from differential sedimentation
* function for c(M) with general scaling law and calibration
* add function to mirror image interference data
* rename pseudo-absorbance data as "AS" and "AR" (absorbance sample side and absorbance reference side)
* add plotting functionality
* add s-value determination from BEST bemine files
* fix potential crash in Rh = 0 case for DLS analysis
* fix bug in integration of distributions with negative s-values
* modify 2d distribution integration
* fix bug causing intermittent crash in Bayesian analysis of 2d distribution
* enable Monte Carlo for 2d distributions
* incorporate HYDROPRO access as a calculator function
|
| | 6/24/2010 1:42 PM | fixed some bugs, couple of improvements to be released with description soon. |
| | 8/31/2009 4:00 PM | fixed a potential crash when Rh = 0 in DLS fit |
| | 7/31/2009 11:59 AM | this is the same as 1180, with a bug fixed where negative s-values as integration limits could cause a crash |
| | 6/29/2009 3:56 PM | changes since last release:
10/10/08: * fix recent bug when using hybrid discrete/continuous model for
sedimentation equilibrium
09/27/08: * eliminate potential problem when using self-association with mass
conservation and linking concentrations from xp with unequal # of scans
renamed version 6.22 beta
09/18/08: * include correction factor for concentrations in isotherms
09/15/08: * improve optimizing extinction coefficient in the multi-wavelength
SV hybrid discrete/continuous model
08/19/08: * allow saving partial boundary raw data
|
| | 6/29/2009 3:54 PM | most important changes from previous release (11.72c):
05/58/09: * fix bug that caused instances where fitted line in plots of isotherm fits was drawn wrong
05/20/09: * modify 2d distribution integration
05/20/09: * fix bug causing intermittent crash in Bayesian analysis of 2d distribution
04/27/09: * enable Monte Carlo for 2d distributions
04/28/09: * incorporate HYDROPRO access as a calculator function
renamed version 11.74
03/12/09: * rotor speed estimator for SE in calculator functions
03/11/09: * minimum time to equilibrium estimator in the calculator functions
03/04/09: * general scaling law model for c(s)
03/04/09: * supress warning about meniscus and bottom fitting limits when not fitting meniscus and bottom
03/04/09: * make wwt option switch back after done with ls-g*(s)
03/04/09: * don't flag fluorescence data for too steep gradients
03/04/09: * make user-defined time interval for updating the best-fit plots during fits
03/04/09: * make model for bimodal frictional ratio with extra species
03/05/09: * allow integrating particle size distributions from DLS
renamed version 11.73a
09/15/08: * include corrections for time-offests in absorbance scans accounting for the scan time from first data point to meniscus
renamed version 11.72f
08/21/08: * make Lamm equation parameter box ask about saving only when anything changes
08/21/08: * rearrange memory allocation at startup for better stability
renamed version 11.72e
08/21/08: * fix overflow error for back-diffusion test of very large species for low values of right fitting limit
|
| | 2/12/2009 2:29 PM | renamed version 11.72c
08/07/08: * fix bug for data that start the comment line with a filetype identifier character
renamed version 11.72b
08/01/08: * fix instability when fitting limits are not set
08/01/08: * fix bug occasionally adding integral offset to dissected 6-channel data
07/31/08: * suppress repainting when loading files and entering parameters.
renamed version 11.72
07/25/08: * fix question to set meniscus and bottom when fitting DLS data
07/25/08: * change compiler optimization settings (Pentium)
07/25/08: * make user defined defaults for Lamm equation parameters
|
| | 2/12/2009 2:29 PM |
renamed version 11.71 07/16/08: * flag gradients that exceed an upper limit 07/15/08: * flag when rotor acceleration is unusually slow (likely error arising from temperature equilibration at 3000 rpm) 07/15/08: * in calculator: fix bug reversing the ellipsoidal ratios of oblate and prolate models 07/05/08: * update xp export file to sedphat 07/03/08: * make debugging system dumping info to files 06/20/08: * make new input box for inhomogeneous solvent model 06/20/08: * make dynamic density gradients take advantage of multi-threaded CLamm class 06/11/08: * include scanning time corrections to ls-g*(s) [is incompatible with compressibility option] 06/11/08: * include scanning time corrections to van Holde-Weischetrenamed version 11.5 (beta) 05/20/08: * fix crash when using van Holde-Weischet model. 05/20/08: * fix bug causing error message when switching models in DLS analysis 05/20/08: * eliminate possibility to transform distributions twice, and to integrate transformed distributionsrenamed version 11.4 05/02/08: * dynamic limit dragging 04/29/08: * take advantage of multithreading for Lamm equation solutions in distributions. 04/23/08: * improve automatic determination of peak width 04/11/08: * fix bug in positioning of the peak Mw info boxes appearing on control-M 04/11/08: * fix bug that would overwrite new vbar value when using the vbar menu function while using continuous distribution models 04/11/08: * enable ls-g*(s) in new Lamm equation class 04/03/08: * make menu point to transform s(xp) to s(20,w) 04/01/08: * fix bug when reloading fit parameters including 'times from wwt' option 04/01/08: * fix bug when generating data with short time interval making a scan time fall into the rotor acceleration phase 04/01/08: * new structure of Lamm equation solutionsrenamed version 11.3c 03/27/08: * fix bug resulting in wrong concentrations when generating data with the discrete species model 03/27/08: * increase precision in the amplitude field of the prior parameter box 03/27/08: * allow fitting of synthetic boundary experiments 03/27/08: * fix bug in Lamm equation parameter box not allowing experimental initial conditions to be switched onrenamed version 11.3b 02/19/08: * fix bug in generating synthetic data with c(s) modelrenamed version 11.3 02/06/08: * make rotor acceleration the default for SV analysis 02/06/08: * change default crossover for sedimentation algorithms 02/06/08: * improved error catching for Lamm simulationsrenamed version 11.2 01/23/08: * fix bug causing crash when using s-grid from file option 01/08/08: * fix bug under certain conditions causing discretization error in Lamm algorithm 01/08/08: * fix bug in switching Lamm simulation methods in distributions at high s-values 01/08/08: * introduce radial reconvolution |